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By contrast, Xu et al (213), using CT26 and SW480 models together with endothelial C166 cells and patient-derived xenografts, reported that GCG administered at 10 nM in vitro and 20 g per mouse daily in vivo for ~14 days inhibited tumor angiogenesis and vascular mimicry and enhanced chemotherapy efficacy, without measurable differences in blood glucose levels among groups

The above changes lead to mitochondrial damage and endoplasmic reticulum stress, interfere with liver metabolic responses, and aggravate liver damage (Dukic et al., 2023)

Am J Clin Nutr 87, 778784 (2008)

Combined with financial stress and social competition, this can accelerate the slide from entertainment to addiction

Im a big believer, that I think that the exercise component could help cellular energetics

Fink-Jensen et al