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When the amino acid supplementation was changed to one with depleted phenylalanine and tyrosine levels, serum T4 and T3 levels gradually decreased

Gut-brain peptides have different functions when administered into the brain relative to the periphery since the blood-brain barrier (BBB) restricts access of peripheral peptides to the CNS

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Following the recommended titration schedule and implementing dietary modifications can help minimise these effects and optimise treatment response

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