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Unlike C- Glud1 / mice, heterozygous C- Glud1 +/ mice show no substantial changes in glutamate levels in hippocampus or PFC, and control-like behavior in a range of cognitive tasks with the exception of the challenging EDSS task [14]

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We conclude that the PZ size, an established readout of Notch activity 19,20,41 , follows DTC-AC levels

Unlike other organelles such as mitochondria, where an abundance of reduced glutathione (GSH) preserves a reductive environment, the ER requires an oxidizing milieu to facilitate the formation of disulfide bonds critical for protein structural integrity

Epilepsia 1988, 29: 543-547