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A classical biomarker of CHO restriction is the amount of circulating KBs

While eating one or two a day is generally considered safe and beneficial for most adults, eating large quantities daily can lead to selenium toxicity (selenosis)

Hamel FG, Peavy DE, Ryan MP, Duckworth WC (1987) HPLC analysis of insulin degradation products from isolated hepatocytes

To this end, we performed a preclinical study in 18-mo-old male and female mice treated with vehicle or an IGF-1R mAb (L2-Cmu, Amgen Inc), and determined effects on aging outcomes

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