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The cumulative transdermal rate (%) was calculated as: where Vi is the volume of the i -th sample aliquot, Ci is the mass concentration of the API in the i -th sample, V is the total volume of the receptor compartment solution, Cn is the API concentration in the n -th sample, and Cm and Vm are the initial API concentration and volume of the medium, respectively

Li Y, Liu A, Chen K, Li L, Zhang X, Zou F, et al

Wipff J, Bonnet P, Ruiz B, Dieude P, Avouac J, Tiev K et al (2010) Association study of serotonin transporter gene (SLC6A4) in systemic sclerosis in European Caucasian populations

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The midline fluid percussion injury model entails delivery of a brief pulse of fluid to the intact dura