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In the cardiovascular system, GLP-1R is known to exist not only on cardiomyocytes and endothelial cells, but also in the autonomic nervous system, Figure 3 suggests that GLP-1R may have direct and indirect effects on the heart and blood vessels

2024;7(11) doi: 10.1001/jamanetworkopen.2024.33000

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Persistent vomiting can lead to dehydration, electrolyte imbalances, delayed wound healing, and increased risk of surgical site complications such as wound dehiscence (separation of wound edges)

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This is particularly relevant for the long-acting weekly formulations, where minor variations in absorption rate would have minimal impact on overall therapeutic effect