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GLP-1 RAs increase glucose-dependent insulin secretion and glucagon suppression, slow gastric emptying, and reduce appetite and body weight, with the overall effect of decreasing HbA1c levels without generally increasing hypoglycemia risk

On the other hand, its glucagon-based action could help the body burn more fat, including harmful visceral and liver fat

Frias JP, Nauck MA, Van J et al (2020) Efficacy and tolerability of tirzepatide, a dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist in patients with type 2 diabetes: a 12-week, randomized, double-blind, placebo-controlled study to evaluate different dose-escalation regimens

It's why we put so much effort into not just our products, but also into sharing the expertise our team has gathered over the years

Current Phase III trials, including the TRIUMPH studies, are assessing the long-term safety and efficacy of retatrutide in various patient groups

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