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In line with this, cells with individual TET gene knockdown exhibited reduced cytosolic NADPH levels and increased sensitivity to glucose starvation, which could not be rescued by antioxidants (NAC or catalase) (Extended Data Fig

Moreover, an elevated concentration of MiR-145 also attenuates cell cycle Cdk4 and Ccnd1 protein expression [79]

Abnormal enzyme activity index is directly associated with the occurrence of various tumors, and can be used as a key index for clinical diagnosis and evaluation of specific diseases

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In the last step, a second GSH is used to regenerate the enzyme and form glutathione disulfide (GSSG) (Savaskan et al., 2007)