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This age-related decline is significant

PMID: 12209581

Pharmacodynamic Effects and Duration Despite measurable plasma clearance, pharmacodynamic effects extend well beyond plasma half-life[20]: Weight loss effects continue throughout treatment with no plateau observed within 48-week study periods Glycemic improvements persist between weekly doses with stable glucose control Appetite suppression effects remain consistent throughout dosing intervals Tissue receptor occupancy likely exceeds plasma peptide concentrations This disconnect between pharmacokinetics and pharmacodynamics suggests prolonged receptor engagement, tissue depot effects, or persistent downstream signaling cascade activation

doi: 10.1079/BJN2003926 125

The copper part is essential to the molecules function, as it carries copper and hands it off where cells can use it

Begin easy with one or two peptides to test tolerance, then add while monitoring effects