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On the other hand, GCN2 can be crucial for CD8 + T cells antitumor immunity against gliomas [154], probably through metabolic adaptations and resistance to cell death

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5.1.3 Chelating agents An alternative approach that mitigates the potential for adaptive resistance involves targeting multiple iron sources through chelating agents (Kontoghiorghes et al., 2010)

TrxR, thioredoxin reductase

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