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They extend the usable life of multi-dose vials by minimizing contamination introduction

Pediatric pharmacokinetics and long-term safety require clarification, particularly for polyphenols and carotenoids with intrinsically low oral bioavailability and potential interactions with conventional medications like antipsychotics or stimulants (Hendouei et al., 2020

Certain medications should not be taken with sulfonamides due to potential drug interactions

10.1016/j.bcp.2018.01.031 152 YangD.YuanW.LvC.LiN.LiuT.WangL.et al (2015)