which glp 1 agonists have cardiovascular benefit View of Diabetes medications with protection after HARMONY Outcomes and DECLARE-TIMI 58: could metformin, pioglitazone, SGLT2 inhibitors and long-acting GLP-1 receptor complement each other to save lives by different mechanisms? GLP-1 receptor agonists improve cardiovascular

Oxidative Stress : Glutathione is a key player in combating oxidative stress

Post-translational modifications modulate proteinopathies of TDP-43, FUS and hnRNP-A/B in amyotrophic lateral sclerosis

Therefore, the research and development of the relevant drugs and the replacement therapy of double GIP-GLP-1R agonists (e.g., tirzepatide) and triple GIP-GCG-GLP-1R (e.g., peptide 20) agonist are key research fields

WARNINGS: Do not use if pregnant or planning to become pregnant or breastfeeding

It is also being explored in combination therapy approaches, particularly in cancer treatment protocols, to enhance treatment effectiveness and reduce side effects [102]

BMJ Open 14 , e074391 (2024)