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The compound is classified as an amylin receptor agonist with demonstrated activity at calcitonin receptor (CTR) and receptor activity-modifying protein (RAMP) complexes, particularly CTR/RAMP1, CTR/RAMP2, and CTR/RAMP3 heterodimers
Computational modeling and docking analysis revealed that both E2 and 4-OHT fit into the putative ligand-binding domain (aa131-294) in ER36 that corresponds to aa302-465 in ER66 (Supplementary information, Figure S8A-S8B)
Because prescription medications that mimic GLP-1 have received widespread attention
Grant, 2019
Side Note: A weight-inclusive approach also means that you, not the diet, are the one giving permission to make these changes
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