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doi: National Kidney Foundation

doi: 10.1056/nejmoa2032183 2 RubinoDAbrahamssonNDaviesMJHesseDGreenwayFLJensenCet al

Vestergaard, M., Macaskill, P., Holt, P

One example escalation schedule observed in Phase 2 obesity trials proceeded broadly as follows: Weeks 14: 2 mg once weekly (initiation phase) Weeks 58: 4 mg once weekly Weeks 912: 8 mg once weekly Weeks 13 onwards: Up to 12 mg once weekly (the maximum dose explored in Phase 2 trials) This is an illustrative example only

WingRRLangWWaddenTASaffordMKnowlerWCBertoniAGet al

Clinical trials have shown that patients who use tirzepatide experience significant weight loss compared to those using single-receptor agonists