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Chemical uncouplers such as dinitrophenol increase the number of fatty acids thatmust be oxidized perATPmade, and once were used as diet pills.Natural uncoupling proteins (UCPs) were later discovered and shown to be involved with regulation of energy balance and heat generation (including in some adults)

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By mimicking natural fullness signals and delaying stomach emptying, these drugs help reduce calorie intake without intense dieting

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