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However, tirzepatide may lead to fewer or less severe nausea symptoms compared to semaglutide, according to studies conducted by independent researchers, such as Phase 3 randomized controlled trials (RCTs) found in PubMed's electronic databases

Obesity affects more than 40% of adults in the United States, making it a significant health issue

Weight loss results vary depending on the patient, treatment plan, and consistency with lifestyle changes

Retatrutide Availability & Timeline Retatrutide is expected to receive FDA approval in mid-2027 with pharmacy availability in late 2027

The 12 mg group achieved 24.2% weight loss at 48 weeks in Phase 2, and 28.7% at 68 weeks in the Phase 3 TRIUMPH-4 trial