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Pharmacoeconomics 30 , 183195 (2012)

These two treatments resulted in comparable changes from baseline in HbA1c (see Table 7)

The harmful effect of sorbitol is connected mainly with its high osmotic pressure and ability to absorb fluids in tissues

The medication also induces significant weight loss, with patients losing an average of 15% to 21% of their body weight in the SURMOUNT obesity trials, with somewhat lower weight loss observed in patients with type 2 diabetes

Since in some of the studies analysed type 2 diabetic patients were treated with metformin, which has been shown to enhance GLP-1 responses [51], any potential difference in GLP-1 secretory responses between type 2 diabetic patients and healthy participants may have been modified by this mechanism

By promoting weight loss and improving metabolic parameters, semaglutide reduces systemic inflammation that may impair brain function