Antioxidants prevent iron accumulation and lipid peroxidation, but do not correct autophagy dysfunction or mitochondrial bioenergetics in cellular models of BPAN
In contrast, the subcutaneously administered GLP-1 analogues have provided strong glucose-lowering efficacy, but still fail to fully normalise glycaemia in a substantial proportion of patients
Linehan E, Dombrowski Y, Snoddy R, Fallon PG, Kissenpfennig A, Fitzgerald DC
Together, they enhance GH and IGF-1 production without causing excessive spikes, resulting in a more stable and natural hormone release pattern
2021;174(3):Itc33-itc48
ASMBS (2021) reports sleeve gastrectomy mortality risk at approximately 0.1% and major complications at approximately 4%, and notes that for many patients with severe obesity, the metabolic and cardiovascular risks of remaining untreated significantly outweigh the surgical risk