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Treatment with semaglutide improved outcomes in both heart failure with reduced ejection fraction and heart failure with preserved ejection fraction groups [39], suggesting broad cardiovascular protective effects across different phenotypes of heart disease

Overall, 58 percent discontinued before seeing any clinical benefit at all

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Certain GLP-1 medications are approved for weight management in people without diabetes who meet eligibility criteria

Effectiveness and safety of GLP-1 receptor agonists versus SGLT-2 inhibitors in type 2 diabetes: an Italian cohort study

In 2025, Novo Nordisk was pushed to cut its sales forecasts for Wegovy, explicitly blaming the rise in compounded alternatives for lost revenue and a sharp decline in its share price