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et al., 2025) (Figure 5)

The study combined four preclinical experiments with a proof-of-concept clinical trial in adults with obesity

Following the identification of specific mutations in the genes encoding collagen types I, III, and V, as well as several collagen processing enzymes, the EDS classification scheme was collapsed into six distinct clinical syndromes (3), emphasizing the molecular basis of each form (Table 1)

This could prevent ferroptosis and lessen inflammation caused by the release of lipid metabolites and damage-associated molecular patterns (Figure 2)

This makes it a popular choice for those seeking to improve their skin's appearance and health

In contrast, systemic rashes or immune-mediated eruptions may appear weeks after initiation or following dose escalation