As an example, Canfosfamide (TLK286, TELCYTA), a cancer cell-activated prodrug, was designed to exploit the elevated levels and the activity of glutathione S-transferase P1-1 (GSTP1-1) that is overexpressed in many human cancer cells (Tew, 2005)
Predicting and Preventing Immune Checkpoint Inhibitor Toxicity: Targeting Cytokines
Hormones, energy levels, stress, sleep, and nutritional status all play a role
Hyaluronic acid helps retain moisture, keeping your skin hydrated and supple
28,29,30,31,32 However, as with MEK or ERK inhibitors, quickly evolving therapy resistance needs to be anticipated, and combination strategies will likely be required to achieve durable responses
Graphical abstract Access this article Similar content being viewed by others Data availability Data that support the findings of this study are available by the Lombardy Region, but restrictions apply to the availability of these data and codes, which were used under license for the current study, and so they are not publicly available
