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Quick Answer: Unopened semaglutide pens must be refrigerated at 36F to 46F (2C to 8C), but after first use, Ozempic may be stored at room temperature up to 86F (30C) for 56 days

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Alongside these medical benefits, there are some risks of negative effects when taking a regular GLP-1 agonist

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In addition, circulating GLP-1 enters circumventricular areas of the CNSsuch as the subfornical organ, the organum vasculosum of the lamina terminalis, the median eminence near the arcuate nucleus, and the area postremathanks to the partial permeability of the bloodbrain barrier.2,3,6 In addition, NTS neurons, which receive peripheral afferent input, synthesise preproglucagon and serve as a source of GLP-1 within the CNS

doi: 10.1093/brain/awac165 280 TristB