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If left unaddressed, a deficiency can result in severe complications, including irreversible nerve damage or memory impairment, making early diagnosis and ongoing treatment essential

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Patients were initiated at a once weekly dose of 0.25 mg and followed a fixed-dose escalation regimen, with dose increases every 4 weeks (to dose levels of 0.5 mg, 1.0 mg, 1.7 mg, and 2.4 mg per week), aiming at reaching the maintenance dose of 2.4 mg (or the corresponding volume of placebo) after 16 weeks

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Rheumatoid arthritis, systemic lupus erythematosus, and sarcoidosis may present with generalized or regional lymph node enlargement