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DR is associated with coronary atherosclerotic heart disease, macrovascular events (including stroke), and all-cause mortality

Tatsunami R, Oba T, Takahashi K, Tampo Y (2009) Methylglyoxal causes dysfunction of thioredoxin and thioredoxin reductase in endothelial cells

It regulates smooth muscle relaxation, promotes vasodilation, and supports healthy blood flow (1)

Histamine intolerance responses often occur when your body doesn't produce enough DAO enzyme

Therefore, future research should prioritize exploring rational combination strategies with conventional therapies (e.g., immunosuppressants, biologics) to assess potential synergistic effects and develop more effective integrated regimens

Furthermore, ncRNAs can serve as scaffolds to recruit chromatin-modifying complexes to specific genomic loci, precisely orchestrating gene expression during cardiac repair