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Yes, GLP-1 must be refrigerated between 36F and 46F (2C to 8C)

Comp Biochem Physiol A Mol Integr Physiol (2004) 138(4):4359.10.1016/j.cbpb.2004.06.003 8 HuleihelMLunenfeldE

Despite its potential, the integration of nanomedicine into clinical practice faces challenges, including the need for rigorous safety evaluations, immune reactions, regulatory approval, long-term stability, and the development of scalable manufacturing processes alongside ethical frameworks

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A complex picture of the effects of bromelain on the immune system is also perceived