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In GD, the major autoantigen (thyroid-stimulating hormone (TSH)-antibody) is to the receptor for the TSH, which causes overproduction of thyroid hormones, resulting in symptoms such as irritability, rapid heartbeat, weight loss, poor tolerance of heat and bulging eyes (Graves orbitopathy) ( Reference Effraimidis and Wiersinga 4 , Reference Marcocci, Kahaly and Krassas 7 , Reference Brent 8 )

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Primers contained extensions for ligation-independent cloning (Supplementary Table 2)

n = 6 mice/group, mean SD were presented

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Regulation of systemic metabolism by the autonomic nervous system consisting of afferent and efferent innervation