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Under acidic TME conditions, FOXP3 + cells act as potent immunosuppressants, and prolonged lactate accumulation induces upregulation of H3K18 lactylation in NKT cells, leading to FOXP3 + NKT cell production (108)

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Glossary of Key Terms References Reynolds JC, Lai RW, et al

Studies have proposed that mitochondria are the primary sites of melatonin synthesis 17

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