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The subcutaneous tissue surrounding the knee provides adequate proximity for peptide diffusion to ligaments, tendons, and the joint capsule

By contrast, It activates ERR, ERR, and ERR, with the strongest reported potency at ERR

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The gluteus medius and minimus tendons attach at the greater trochanter and frequently develop degenerative changes, partial tears, or inflammation

ATGL-deficient mice showed a two-fold increase in body fat [52] and accumulated TAGs in tissues [53]