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Notably, metabolites involved in PPP, purine and pyrimidine metabolism were slightly decreased, whereas TCA cycle intermediates increased in HeLa cells expressing Cr GPDH compared to luciferase (LUC) control ( Figure 3e-h )

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In addition to their glucose-lowering properties with low risk of hypoglycaemia, GLP-1RAs reduce body weight and show promising results in reducing cardiovascular risk and renal complications in high-risk individuals with T2D