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Simultaneously, carotenoids accumulate in the stratum corneum, producing a gradual yellow-orange hue that becomes visible over time, particularly in low-melanin and sun protected areas such as the palms or inner arms (Figure 5)

However, it is rapidly degraded by dipeptidyl peptidase-4 (DPP-IV) and other serum proteases, giving it a half-life of only 10-20 minutes

Vascul Pharmacol 2019;120:106565

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The lyophilized powder should be stored at 2-8C in dry conditions to maintain molecular integrity and prevent degradation that could affect research results