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This restriction is in place because methylene blue is a potent drug with significant physiological effects and risks (like serious drug interactions and contraindications), so its use must be professionally supervised

and neural network damage, iron deposition leads to axonal injury by utilizing the iron sensibility of oligodendrocytes

Since our proteomic study suggested mitochondrial alterations following HC treatment, and considering the recent hypothesis of Simeone (Simeone, 2025) that HC might interact with key cellular antioxidant systems, mitochondrial function was further investigated through oxygen consumption rate (OCR), extracellular acidification rate (ECAR), mitochondrial membrane potential, mitochondrial network morphology, ROS production and GSH/GSSG ratio

Nilotinib effects on safety, tolerability, and potential biomarkers in Parkinson disease