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This contraindication stems from observations in rodent studies where tirzepatide and similar GLP-1 receptor agonists caused thyroid C-cell tumors at clinically relevant exposures
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Consistent with these findings, supplementation of only GSH/GSHee, but not other antioxidants (Trolox, Ferrostatin-1) prevented induction in SLC25A39 protein levels upon GSH depletion (Fig
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Not because they're miscounting, but because their resting metabolic rate has adapted downward and their body is partitioning calories toward fat storage rather than oxidation
