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It followed adults with obesity or overweight (without type 2 diabetes) over 48 weeks

Nature Communications (2025) 11

Mechanisms reported in the literature include: GLP-1 receptor activation Stimulates glucose-dependent insulin release Supports appetite regulation and satiety signaling Slows gastric emptying GIP receptor activation Augments insulin secretion Associated with -cell support and improved nutrient handling Glucagon receptor activation Linked to increased energy expenditure Promotes hepatic lipid mobilization and oxidation Clinical Research Evidence In a published Phase 2 randomized trial, retatrutide produced dose-dependent reductions in body weight, with the highest dose associated with up to approximately 24% mean body-weight reduction at 48 weeks , alongside improvements in cardiometabolic markers

Semaglutide has years of post-marketing surveillance data from millions of users

Rheumatology 50 , 973981 (2011)

30-53% of new cases are directly linked to obesity