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Firstly, activated NF-B and NLRP3 inflammasome in DN promotes inflammation and increases fibronectin and collagen deposition in kidney, 41,42 leading to thickening glomerular basement membrane, glomerular sclerosis, podocyte damage, and ultimately kidney fibrosis

El Samaloty, N.M., Z.A

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But KY19382, a small molecule that inhibits both CXXC5 function and GSK3-beta simultaneously, completely restored beta-catenin signaling even in the presence of DHT