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Individuals with the TT genotype may experience subtle differences in how efficiently neurons strengthen connections in response to learning, stress adaptation, or cognitive stimulation

A: Indirectly yes

By doing so, it interacts with the brain to help you feel full sooner and stay full for a longer duration

Human studies have been more limited

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[48] Clowes proposed a collaboration with the researchers in December 1921, and then again March and May 1922