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The purpose of this review is to evaluate the importance of the transsulfuration pathway in these cells, particularly in the context of a reserve pathway that channels methionine towards cysteine when the demand for glutathione is high, or under conditions in which the supply of cystine by the x c exchanger may be compromised

While extensive epidemiological studies have consistently indicated a significant neuroprotective effect, the most conclusive clinical trials in Alzheimers disease have not corroborated this benefit, presenting a critical conundrum for the field

Durability of response: can histologic gains be maintained beyond two years, and does early improvement translate into a reduced risk of cirrhosis, HCC, or the need for a transplant

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Course length varies by cause

Lekounoungou, F.L