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In contrast to GIPRs, GLP-1Rs are not expressed in adipose tissue (170)

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Once released, GLP-1 enters the bloodstream and attaches to specific GLP-1 receptors

Wright, A

Two large 72-week clinical trials that evaluated terzepatide in individuals who were overweight or obese found that by the end of the study, people who also dieted and exercised reported statistically significant weight loss compared to those who took the placebo