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Direct stimulation of -cell D2R and D3R with dopamine (DA) or D2R/D3R agonists inhibits glucose-stimulated insulin secretion (GSIS) in both human and mouse pancreatic islets 6,7,8,10 , suggesting that -cell D2R/D3R signaling is an important regulator of GSIS 5,6,8,9

J.DickersonB.et al (2022)

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Gilardi, M.T

In China, the prevalence of hyperuricemia among CKD patients varies from 36.6% to 50%, with a notable rise observed as CKD progresses

Tirzepatide the FDA label directs initiation at 2.5 mg once weekly, with escalation in 2.5 mg steps at intervals of at least four weeks to a maximum of 15 mg weekly