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doi: 10.1089/ars.2007.1957 281 TrapaniV.RosanoffA.BaniasadiS.BarbagalloM.CastiglioniS.Guerrero-RomeroF.et al
Lancet 395:497506
Off-label and alternative uses discussed in the public domain include skin quality support (due to copper peptide biology), post-procedure recovery support, and general repair signaling support during rehabilitation
Time alone is enough reason to replace it
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The reasons for the wide-spread use of this test are the ease of performing the single intervention, the reproducible and spontaneous pain-related responses that can be observed in unrestrained animals, and finally, the 2 separately interpretable readouts
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