La evidencia reciente ha demostrado beneficios teraputicos en: eventos cardiovasculares mayores, insuficiencia cardaca con fraccin de eyeccin preservada, prevencin de diabetes, apnea obstructiva del sueo, enfermedad arterial perifrica, enfermedad renal crnica y esteatohepatitis asociada a disfuncin metablica (MASH)
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Further research into GLP-1 suggests it has actions outside of its effects on glucose homeostasis
An anion exchange chromatography process for purifying a peptide or GLP-1 peptide from a mixture comprising said peptide or GLP-1 peptide and related or unrelated impurities, comprising the step of: separating said peptide or GLP-1 peptide and said related or unrelated impurities of said mixture by elution in a solution comprising an organic modifier, water, optionally a salt component, and optionally a buffer, with a linear or step gradient or isocratically in salt component and/or with a linear or step pH-gradient or at a constant pH-value, wherein the pH-gradient or pH-value should be in the range where said peptide or GLP-1 peptide has a negative local or overall net charge different from the local or overall negative net charge of said related or unrelated impurities so as to remove said related or unrelated impurities
