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It was found that the BICD2 gene in the peripheral blood of MDD patients and depressed mice showed DNA hypermethylation and mRNA downregulation, while the BICD2 gene in the hippocampus of depressed mice showed DNA hypomethylation and mRNA and protein up-regulation, and the BICD2 protein was also up-regulated in the hippocampus of MDD patients after death

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