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The metformin research suggests plausibility for similar effects with semaglutide , but the mechanisms differ enough that direct extrapolation remains uncertain

[4] For example, biotin-dependent enzymes facilitate the conversion of pyruvate to oxaloacetate (an important step in gluconeogenesis), the synthesis of malonyl-CoA from acetyl-CoA (the first step in fatty acid biosynthesis), and the catabolism of certain amino acids into Krebs cycle intermediates

doi: 10.1124/jpet.119.258152