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B12 deficiency itself commonly causes fatigue and disrupted sleep patterns, which improve with appropriate treatment

J Child Neurol, 2008

In the SURMOUNT-1 trial, people treated with tirzepatide lost up to 22.5% of their body weight over 72 weeks , making it even more effective than semaglutide (NEJM tirzepatide study)

Conclusions Thyroid dysfunction, particularly hypothyroidism and Hashimotos thyroiditis, is closely linked to increased cardiovascular risk through mechanisms involving immune dysregulation, oxidative stress, and hormonal imbalance

Respecto al manejo farmacolgico, se recomienda utilizar laxantes osmticos como primera lnea de manejo, siendo el frmaco de eleccin el polietilenglicol a dosis de 17g da con titulacin

But, if these metals accumulate in the body in concentrations sufficient to cause poisoning, then serious damage may occur