[7] The resulting half-life of active GLP-1 is approximately 2 minutes, which is however sufficient to activate GLP-1 receptors
It's not about being overly cautious
In animal studies, GLP-1 receptor agonists have been associated with thyroid C-cell tumours, though this finding has not been established in humans
Aitken RJ, Ryan AL, Curry BJ, Baker MA: Multiple forms of redox activity in human spermatozoa
Pros and Cons: A Balanced Risk Assessment Potential 'Pros' (Theoretically Claimed): No UV exposure required (though unsafe alternative) Perceived convenience over topical applications Documented Cons: Severe nausea/vomiting (70-80% of users) 10 Unpredictable skin darkening (patchy results, permanent freckling) Increased mole count and darkening (melanoma risk factor) 11 Zero quality control (contamination risks with bacteria/endotoxins) Legal consequences (classified as unapproved drugs in US/EU) When it might be 'suitable': Never for cosmetic use
PlexusDx provides compounded semaglutide from licensed 503A pharmacies that include detailed storage instructions and visual-inspection guidelines with each shipment
