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Moreover, the imbalance of the antioxidant system further exacerbates lipid ROS accumulation: when the glutathione peroxidase 4 (GPX4), ferroptosis suppressor protein 1 (FSP1)-coenzyme Q10 (CoQ10), and dihydroorotate dehydrogenase (DHODH)-CoQ10 axes are restricted, lipid peroxides cannot be reduced, leading to the continuous accumulation of ROS [147]

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