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The primary alterations noted in FM include monoaminergic neurotransmission dysfunctions, which result in increases in excitatory neurotransmitters like substance P and glutamate and decreases in spinal cord serotonin and norepinephrine levels at the descending anti-nociceptive pathway level

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According to a study, almost 22% of people with diabetes were low in B-12, suggesting that metformin is the reason

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