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Some of the inconsistency across preclinical reports reflects differences in the compounds, doses, and assay conditions used, so standardised reporting of peptide characterisation and experimental conditions would make the literature easier to interpret and to replicate

In physiological conditions this receptor is down-regulated while with aging its expression increases, probably due to the accumulation of ligands which, through positive feedback, regulate the expression of receptor itself [40, 41, 42]

doi: 10.1038/sj.embor.embor729