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335,336 Further, the GLP-1/GIP dual-agonist tested in this study, MAR709, lost its superior efficacy on body weight and food intake over GLP-1 in the CNS-GIPR knockout mice, suggesting that this dual-agonist mediates part of its action via the CNS-GIPR

Graphical abstract Access this article Similar content being viewed by others Data availability Data that support the findings of this study are available by the Lombardy Region, but restrictions apply to the availability of these data and codes, which were used under license for the current study, and so they are not publicly available

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doi: 10.1111/dom.12432 64 GeS.GohE

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Because of this, carefully designed experiments with NEP21.11 and ANP and/or NRP-1 knockdowns may be required to further parse the role of GLP-1(2836) in the overall cardiovascular biology of GLP-1