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Nature immunology 13 , 387395, doi: 10.1038/ni.2239 (2012)
Schirra J, Nicolaus M, Roggel R, Katschinski M, Storr M, Woerle HJ, et al
Dihexa consistently outperformed these analogs, likely due to its superior metabolic stability and enhanced c-Met binding affinity
6.1 A possible peripheral contribution to altered eating experience Basic studies indicate that GLP-1-related signalling components are present within taste buds and may participate in the local modulation of gustatory information, particularly in pathways related to sweet taste and energy intake (87)
For all-cause mortality, the five-year survival probability was 96.9% with GLP-1RAs and 82.3% with insulin/metformin