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This is particularly important at the cellular level because oxidation reactions lead to the formation of FR and contribute to various diseases

More serious but less common risks include acute pancreatitis, gallbladder disease, acute kidney injury (usually secondary to dehydration from gastrointestinal losses), and hypoglycemia when used in combination with insulin or sulfonylureas

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Patients prescribed insulin may have a longer history of diabetes and more severe complications [44], which could increase their risk of gastrointestinal issues

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NCT numbers from ClinicalTrials.gov